Typically, each cell contains around 1,000 mitochondria, analogous to having 1,000 batteries in a UPS system to ensure continuous power supply to a house. Remarkably, heart cells contain about 7,000 mitochondria each. When these mitochondria are damaged, it leads to a "power cut" in the heart, impairing its ability to pump blood. This can result in a heart attack or reduced blood flow to the brain, causing a stroke.

Therefore, testing mitochondrial health at the cellular level is vital for accurate diagnosis and effective treatment of diseases, maintaining good health, and preventing infertility and premature aging. This testing is also useful for comparing chronological age with biological age


MFusion Indicates the level of mitochondrial fusion.
Mfission: Indicates the level of mitochondrial fission.
AuTG: Indicates the level of mitochondrial autophagy.
COX : Indicates the level of mitochondrial functionality.
A higher ratio of mitochondrial fission to fusion indicates significant mitochondrial damage needing correction. A lower ratio suggests excess fusion, which can overload and shut down power supply, akin to overloading batteries in a UPS system. A lower ratio of autophagy to functionality indicates aged mitochondria and increased ROS production. Conversely, a higher ratio suggests lower quality mitochondria and reduced functionality.

Damaged mitochondria not only produce less ATP but also generate higher levels of reactive oxygen species (ROS). If these reactive species are not removed promptly, they cause oxidative stress and damage various organs. Mitophagy, a form of autophagy, helps remove dysfunctional mitochondria. However, excessive mitophagy can reduce the number of mitochondria, leading to energy deficits and diseases in the nervous system, cardiovascular system, lungs, liver, kidneys, sexual organs and skeletal muscles.

Stress and diets low in polyphenols can disrupt the balance of new mitochondria production and the removal of damaged ones. Excessive energy production can also accelerate cancer cell growth and metastasis, and confuse the pancreas, potentially leading to diabetes.

Treatment?

we also offer treatment suggestions to improve mitochondria performance.


Mitochondrial Genetic Testing can serve various purposes, including:

Diagnosis of Mitochondrial Disorders:

Mitochondrial disorders are a group of genetic conditions that can affect various body systems due to energy production problems. These disorders can result from mutations in either nuclear DNA or mitochondrial DNA (mtDNA). Testing can help diagnose the specific genetic cause of a patient's symptoms and guide appropriate medical management.

Assessment of Genetic Inheritance:

Mitochondrial DNA is typically inherited from the mother. This means that if a mother has a mitochondrial DNA mutation, all of her children may inherit the mutation. Testing can be used to assess the likelihood of passing on mitochondrial disorders to future generations.

Identification of Heteroplasmy:

Mitochondrial DNA mutations can sometimes exist in a mixture of normal and mutated forms within an individual, a condition known as heteroplasmy. The severity of symptoms in mitochondrial disorders can depend on the proportion of mutated mtDNA. Testing can help determine the level of heteroplasmy in a person's cells.

Research and Understanding:

Studying Mitochondrial DNA can provide insights into human evolution, population genetics, and migration patterns. It's also important for understanding the basic biology of mitochondria and how their genetic material affects cellular function.

Forensic Analysis:

Mitochondrial DNA can be more stable than nuclear DNA and is sometimes used in forensic analysis to identify individuals when nuclear DNA is degraded or unavailable.

Different methods for conducting mitochondrial genetic testing:

Sequencing:

Sequencing the entire mitochondrial genome can identify mutations associated with mitochondrial disorders and help determine heteroplasmy levels.

Targeted Mutation Analysis:

If a specific mutation is suspected based on clinical symptoms, targeted testing can be performed to confirm the presence of that mutation.

Heteroplasmy Assessment:

Techniques like quantitative PCR (Polymerase Chain Reaction) can help quantify the proportion of normal and mutant mitochondrial DNA.


Next-Generation Sequencing:

Advanced sequencing technologies can quickly and efficiently sequence large numbers of mitochondrial genomes, aiding in research and diagnostics.